SULFONAMIDE CLASS ANTIBIOTICS

SULFONAMIDE CLASS ANTIBIOTICS


Sulfonamide is an organic sulfur compounds containing the radical -SO₂NH₂ (the amides of sulfonic acids). Its molecular structure is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides, derived from chiefly sulfanilamide, are capable of interfering with the metabolic processes in bacteria that require PABA. They act as antimicrobial agents by inhibiting bacterial growth and activity and called sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. Sulfa drug includes; -Topical sulfonamides: sulfacetamide; silver sulfadiazine; mafenide; mafenide acetate; -Rapidly absorbed and eliminated sulfonamides: sulfisoxazole diolamine; sulfadiazine; sulfamethoxazole; -Hydrophylic sulfonamides: phtalylsulfacetamide; phtalylsulfathiazole; sulfasalazine; sulfaguanidine; -Long lasting sulfonamides: sulfadoxine; -Others: sulfamazole; sulfamazone; sulfametopirazine; sulfametoxypiridazine; sulfametrol; succinylsulfathiazole;

MAFENIDE CAS NUMBER : 138-39-6 (Base), 13009-99-9 (Acetate) EINECS NUMBER : CHEMICAL NAME(S): 4-(Aminomethyl)benzenesulfonamide; 4-Homosulfanilamide; Paramenyl; alpha-Amino-p-toluenesulfonamide; Ambamide; Emilene; Homonal; Homosulfamine; Mafenide; Maphenide; Marfanil; Mesudin; Mesudrin; Neofamid; Septicid; Sulfamylon; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₇H₁₀N₂O₂S (186.23)

PHTALYLSULFATHIAZOLE CAS NUMBER : 85-73-4 EINECS NUMBER : 201-627-4 CHEMICAL NAME(S): 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]benzoic acid; 4¢-(2-thiazolylsulfamyl)phthalanilic acid; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₇H₁₃N₃O₅S₂(403.43)

SUCCINYLSULFATHIAZOLE CAS NUMBER : 116-43-8 EINECS NUMBER : 204-141-0 CHEMICAL NAME(S): N1-(2-thiazolyl)-n4-succinoylsulfanilamide; 2-(N(4)-Succinylsulfanilamido)thiazole; p-2-Thiazolylsulfamoylsuccinanilic acid; 4'-(2-Thiazolylsulfamoyl)succinanilic acid; Sulfadigesin; Sulfasuccidine; Sulfasuccinil; Sulfasuccithiazole; Sulfasuxidine; Sulfenterone; Thiacyl; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₃H₁₃N₃O₅S₂(355.38)

SULFACETAMIDE CAS NUMBER : 144-80-9 (Base), 127-56-0 (Sodium) EINECS NUMBER : 205-640-6 CHEMICAL NAME(S): p-aminobenzenesulfonacetamide; acetocid; acetosulfamine; albamine; albucid; formosulfacetamide; N-((4-aminophenyl)sulfonyl) Acetamide; N-acetyl-4-aminobenzenesulfonamide; N-acetyl-4-aminobenzenesulfonic acid amide; N-acetylsulfanilamide; N-sulfanilylacetamide; N(sup 1)-acetyl-4-aminophenylsulfonamide; Sulfacetamide; sulfacetimide; sulfacyl; sulfanilacetamide; sulfanilamide, Sultrin; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₈H₁₀N₂O₃S (214.24)

SULFADIAZINE CAS NUMBER : 68-35-9 (Base), 22199-08-2 (Silver), 547-32-0 (Sodium) EINECS NUMBER : 200-685-8 CHEMICAL NAME(S): Adiazine; 4-amino-N-2-pyrimidinyl-benzenesulfonamide; Diazolone; N1-(2-Pyrimidinyl)-sulfanilamide; Sulfadiazine; Sulfadiazina; Sulfacombin; Sulfapyrimidine; Sulfolex; Theradiazine; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₀H₁₀N₄O₂S (250.27)

SULFADOXINE CAS NUMBER : 2447-57-6 EINECS NUMBER : CHEMICAL NAME(S): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide; 4-Sulfanilamido-5,6-dimethoxypyrimidine; 6-(4-Aminobenzenesulfonamide)-4,5-dimethoxypyrimidine; 6-(4-Aminobenzenesulfonamido)-4,5-dimethoxypyrimidine; Fansidar (suldfadoxine and pyrimethamine); N-(5,6-Dimethoxy-4-pyrimidinyl) sulfanilamide; N'-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide; Sulforthomidine; Sulfadoxine; Sulformethoxine; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₂H₁₄N₄O₄S (310.33)

SULFAMAZONE CAS NUMBER : 65761-24-2 EINECS NUMBER : CHEMICAL NAME(S): CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₂₃H₂₄N₆O₇S₂(560.60)

SULFAMETHAZINE CAS NUMBER : 57-68-1 EINECS NUMBER : 200-346-4 CHEMICAL NAME(S): -Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide; 4,6-Dimethylsulfadiazine; Sulfadimidine; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₃H₁₅N₃O₂S (277.34)

SULFAMETHOXAZOLE CAS NUMBER : 723-46-6 EINECS NUMBER : CHEMICAL NAME(S): CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₀H₁₁N₃O₃S (253.28)

SULFAMETOPIRAZINE

SULFAMETOXYPIRIDAZINE

SULFAMETROL CAS NUMBER : 32909-92-5 EINECS NUMBER : CHEMICAL NAME(S): CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₉H₁₀N₄O₃S₂(286.32)

SULFAMONOMETHOXINE CAS NUMBER : 1220-83-3 EINECS NUMBER : CHEMICAL NAME(S): 4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₁H₁₂N₄O₃S (280.30)

SULFAMYLON CAS NUMBER : 138-37-4 EINECS NUMBER : CHEMICAL NAME(S): 4-(Aminomethyl)benzenesulfonamide hydrochloride; 4-(Aminomethyl)benzenesulfonamide monohydrochloride; alpha-Amino-p-toluenesulfonamide hydrochloride; Homosulfamine Hydrochloride; Homosulfanilamide hydrochloride; Mafenide hydrochloride; Sulfamylon; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₇H₁₁ClN₂O₂S (222.69)

SULFANILAMIDE CAS NUMBER : 63-74-1 EINECS NUMBER : 200-563-4 CHEMICAL NAME(S): 4-Aminobenzenesulfonamide; sulfocidine; Sulfonamide; p-Aminophenylsulfonamide; p-Anilinesulfonamide; p-Sulfamidoaniline; Aminobenzenesulfonamide; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₆H₈N₂O₂S (172.20)

SULFAQUINOXALINE CAS NUMBER : 59-40-5(Base), 967-80-6 (Sodium) EINECS NUMBER : 200-423-2 CHEMICAL NAME(S): 2-(p-aminobenzenesulfonamido)thiazole; 2-sulfanilamidothiazole; Amino-N-2-thiazolylbenzenesulfonamide; Benzenesulfonamide, 4-amino-N-2-thiazolyl-; cibazol; N1-(2-Thiazolyl)Sulfanilamide; N(sup1)-2-thiazoylsulfanilamide; Sulfanilamide, N1-2-thiazolyl-; Sulfathiazole; Sulfathiozole; Thiazamide; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₄H₁₂N₄O₂S (300.33)

SULFASALAZINE CAS NUMBER : 599-79-1 EINECS NUMBER : 209-974-3 CHEMICAL NAME(S): 2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo] Benzoic acid; 5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid; Aazopyrin; Azulfidine; Salazopyrin; Salazosulfapyridine; Salicylazosulfapyridine; Sulfasalazine; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₈H₁₄N₄O₅S (398.39)

SULFATHIAZOLE CAS NUMBER : 72-14-0(Base), 144-74-1 (Sodium) EINECS NUMBER : 200-771-5 CHEMICAL NAME(S): 2-(p-Aminobenzenesulfonamido)thiazole; 2-Sulfanilamidothiazole; Amino-N-2-thiazolylbenzenesulfonamide; Benzenesulfonamide, 4-Amino-N-2-thiazolyl-; cibazol; N1-(2-Thiazolyl)Sulfanil Amide; N(sup1)-2-thiazoylsulfanilamide; Thiazamide; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₉H₉N₃O₂S₂ (255.31)

SULFISOXAZOLE CAS NUMBER : 127-69-5 EINECS NUMBER : 204-858-9 CHEMICAL NAME(S): 3,4-Dimethyl-5-sulfanilamidoisoxazole; 3,4-Dimethylisoaxazole-5-sulfanilimide; 5-(p-Aminobenzenesulfonamido)-3,4-Dimethylisoxazole; 5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole; 5-Sulfanilamido-3,4-dimethyl-isoxazole; N(sup 1)-(3,4-dimethyl-5-isoxazolyl)-sulfanilamide; Sulfisoxazole; 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfon Amide; N¹-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₁₁H₁₃N₃O₃S (267.30)

SULFISOXAZOLE DIOLAMINE

SULFAGUANIDINE CAS NUMBER : 57-67-0 EINECS NUMBER : 200-345-9 CHEMICAL NAME(S): 4-Amino-N-(diaminomethylene)benzenesulfon Amide; N1-Amidinosulfanilamide; Ny-Amidinosulfanilamide, 99%; Sulfaguanidine; 4-Amino-N-guanylbenzenesulfon Amide; Sulfanilyl guanadine; CLASSIFICATION: Antibiotic > Anti-Metabolite > SULFONAMIDE	C₇H₁₀N₄O₂S (214.24)